Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex

Samuel K. Appiah; Charles Nkansah; Kofi Mensah; Felix Osei-Boakye; Dorcas Serwaa; Simon B. Bani; Gabriel Abbam; Samira Daud; Mandeiya D. A. Yakubu; Abraham B. Sagoe; Charles A. Derigubah; Yeduah Quansah; Vincent Kawuribi

doi:10.28991/SciMedJ-2022-04-02-02

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Samuel K. Appiah
appiahs30@yahoo.com
1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,, Nigeria
Charles Nkansah 1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,, Nigeria http://orcid.org/0000-0001-6986-9976
Kofi Mensah 1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,, Nigeria
Felix Osei-Boakye Department of Medical Laboratory Technology, Faculty of Applied Science and Technology, Sunyani Technical University, Sunyani,, Ghana
Dorcas Serwaa Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne,, Australia
Simon B. Bani Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana
Gabriel Abbam Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale,, Ghana
Samira Daud Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale,, Ghana
Mandeiya D. A. Yakubu Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana
Abraham B. Sagoe Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana
Charles A. Derigubah Department of Medical Laboratory Technology, School of Applied Science and Arts, Bolgatanga Technical University, Bolgatanga,, Ghana
Yeduah Quansah Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana
Vincent Kawuribi Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana

Vol. 4 No. 2 (2022): June

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Background: The ABO blood antigens may influence the levels of vWF: Ag and put individuals at risk of coagulopathies. This study assessed the plasma vWF: Ag and its relation with ABO blood antigens among healthy adults in northern Ghana. Methods: This cross-sectional study recruited 84 blood donors, aged 1850 years, at Tamale Teaching Hospital. Blood groups were determined using the standard tube method, and a complete blood count was measured with an automated haematology analyzer. Sandwich ELISA was used to assess plasma vWF: Ag levels. The data obtained were analyzed using SPSS version 22. Results: The frequencies of O, A, B, and AB blood groups were 34 (40.5%), 25 (29.8%), 20 (23.8%), and 5 (6.0%), respectively. vWF: Ag levels were higher among the non-O than group O individuals (p = 0.008). Plasma vWF: Ag levels were lower in group O compared to AB (p = 0.015) and A (p = 0.013) individuals. Males had higher vWF: Ag levels than females (p = 0.002). A moderately positive correlation was observed between age and vWF levels (r = 0.497, p<0.001). Blood group O participants had lower absolute neutrophil counts (p = 0.039), but higher RDW-SD (p = 0.045). Conclusion: The predominant blood group was O, followed by other groups in the order: O>A>B>AB. Plasma vWF: Ag levels were higher in non-group O compared with group O individuals. Males had higher vWF: Ag levels, and a positive correlation between age and vWF: Ag was observed. Again, blood group O participants had lower neutrophil counts, but higher RDW-SD. The relationship between ABO blood phenotypes and plasma vWF: Ag should be considered in clinical practice. The establishment of separate reference intervals of vWF: Ag for the various phenotypes of ABO is recommended. Also, the study recommends further multicenter studies to assess the link between ABO phenotypes and all the endothelial cell parameters.

Doi: 10.28991/SciMedJ-2022-04-02-02

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Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex

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